Lee Sang Hyub, Ryu Ji Kon, Lee Kyeung-Yeup, Woo Sang Myung, Park Joo Kyung, Yoo Ji Won, Kim Yong-Tae, Yoon Yong Bum
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 110-744, Yeongeon-dong 28, Jongno-gu, Seoul, Republic of Korea.
Cancer Lett. 2008 Jan 18;259(1):39-49. doi: 10.1016/j.canlet.2007.09.015. Epub 2007 Oct 29.
Apigenin is a dietary flavonoid possessing therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and apigenin enhanced anti-tumor efficacy in pancreatic cancer. In vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of NF-kappa B activity with suppression of Akt activation in pancreatic cancer cell lines (MiaPaca-2, AsPC-1). In vivo, the combination therapy augmented tumor growth inhibition through the down-regulation of NF-kappa B activity with the suppression of Akt in tumor tissue. The combination of gemcitabine and apigenin enhanced anti-tumor efficacy through Akt and NF-kappa B activity suppression and apoptosis induction.
芹菜素是一种具有抗癌治疗潜力的膳食类黄酮。本研究旨在探讨吉西他滨与芹菜素联合治疗是否能增强胰腺癌的抗肿瘤疗效。在体外，联合治疗通过下调核因子κB活性并抑制胰腺癌细胞系（MiaPaca-2、AsPC-1）中的Akt激活，导致更多的生长抑制和细胞凋亡。在体内，联合治疗通过下调肿瘤组织中的核因子κB活性并抑制Akt，增强了肿瘤生长抑制。吉西他滨与芹菜素联合使用通过抑制Akt和核因子κB活性以及诱导细胞凋亡，增强了抗肿瘤疗效。
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