Thyagarajan Anita, Forino Andrew S, Konger Raymond L, Sahu Ravi P
Department of Pharmacology and Toxicology, Boonshoft School of medicine Wright State University, Dayton, OH 45435, USA.
Department of Anatomy and Physiology, Boonshoft School of medicine Wright State University, Dayton, OH 45435, USA.
Antioxidants (Basel). 2020 Jul 23;9(8):651. doi: 10.3390/antiox9080651.
Naturally occurring dietary agents present in a wide variety of plant products, are rich sources of phytochemicals possessing medicinal properties, and thus, have been used in folk medicine for ages to treat various ailments. The beneficial effects of such dietary components are frequently attributed to their anti-inflammatory and antioxidant properties, particularly in regards to their antineoplastic activities. As many tumor types exhibit greater oxidative stress levels that are implicated in favoring autonomous cell growth activation, most chemotherapeutic agents can also enhance tumoral oxidative stress levels in part via generating reactive oxygen species (ROS). While ROS-mediated imbalance of the cellular redox potential can provide novel drug targets, as a consequence, this ROS-mediated excessive damage to cellular functions, including oncogenic mutagenesis, has also been implicated in inducing chemoresistance. This remains one of the major challenges in the treatment and management of human malignancies. Antioxidant-enriched natural compounds offer one of the promising approaches in mitigating some of the underlying mechanisms involved in tumorigenesis and metastasis, and therefore, have been extensively explored in cancer chemoprevention. Among various groups of dietary phytochemicals, polyphenols have been extensively explored for their underlying chemopreventive mechanisms in other cancer models. Thus, the current review highlights the significance and mechanisms of some of the highly studied polyphenolic compounds, with greater emphasis on pancreatic cancer chemoprevention.
天然存在于多种植物产品中的膳食成分是具有药用特性的植物化学物质的丰富来源，因此，长期以来一直被用于民间医学治疗各种疾病。这类膳食成分的有益作用通常归因于它们的抗炎和抗氧化特性，特别是在它们的抗肿瘤活性方面。由于许多肿瘤类型表现出更高的氧化应激水平，这与促进自主细胞生长激活有关，大多数化疗药物也可部分通过产生活性氧（ROS）来提高肿瘤的氧化应激水平。虽然ROS介导的细胞氧化还原电位失衡可提供新的药物靶点，但因此，这种ROS介导的对细胞功能的过度损伤，包括致癌性诱变，也与诱导化疗耐药有关。这仍然是人类恶性肿瘤治疗和管理中的主要挑战之一。富含抗氧化剂的天然化合物为减轻肿瘤发生和转移中涉及的一些潜在机制提供了一种有前景的方法，因此，已在癌症化学预防中得到广泛探索。在各类膳食植物化学物质中，多酚已在其他癌症模型中对其潜在的化学预防机制进行了广泛研究。因此，本综述强调了一些经过深入研究的多酚化合物的重要性和作用机制，更侧重于胰腺癌的化学预防。
