取代的3-亚苄基-7-烷氧基色满-4-酮的合成及其抗氧化性能
Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones.
作者信息
Foroumadi Alireza, Samzadeh-Kermani Alireza, Emami Saeed, Dehghan Gholamreza, Sorkhi Maedeh, Arabsorkhi Fatemeh, Heidari Mahmoud Reza, Abdollahi Mohammad, Shafiee Abbas
机构信息
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran.
出版信息
Bioorg Med Chem Lett. 2007 Dec 15;17(24):6764-9. doi: 10.1016/j.bmcl.2007.10.034. Epub 2007 Oct 17.
A series of 3-benzylidene-7-alkoxychroman-4-one derivatives were synthesized and evaluated for their antioxidant activities. The antioxidant activity was assessed using three methods, namely, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), and thiobarbituric acid reactive substances (TBARS) assays. 3-Benzylidene-7-alkoxychroman-4-one derivatives bearing catecholic group on benzylidene moiety exhibited excellent antioxidant activity. Compounds having catechol moiety exhibited potent antioxidant activities in all tested methods and they were more active than the reference drug, Trolox.
合成了一系列3-亚苄基-7-烷氧基色满-4-酮衍生物，并对其抗氧化活性进行了评估。采用三种方法评估抗氧化活性，即1,1-二苯基-2-苦基肼（DPPH）自由基清除法、铁离子还原抗氧化能力（FRAP）法和硫代巴比妥酸反应性物质（TBARS）测定法。在亚苄基部分带有儿茶酚基团的3-亚苄基-7-烷氧基色满-4-酮衍生物表现出优异的抗氧化活性。具有儿茶酚部分的化合物在所有测试方法中均表现出较强的抗氧化活性，且它们比参比药物Trolox更具活性。
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