Velazquez E, Montes A, Ruiz-Albusac J M
Departamento de Bioquímica, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
Biomed Biochim Acta. 1991;50(9):1109-14.
The in vitro transfer of radiolabelled unesterified cholesterol from human low- and very low- to high-density lipoproteins in the presence of either lipoprotein deficient serum or bovine serum albumin has been studied. The rate of transfer was faster from LDL (t1/2 = 44 min) than from VLDL (55 min). The presence of 2% protein had no effect on the transfer. However, 10% albumin or lipoprotein deficient serum reduced t1/2 by 35%, which indicates no specific effect of a plasma protein on the rate of transfer of unesterified cholesterol.
在脂蛋白缺乏血清或牛血清白蛋白存在的情况下，对放射性标记的未酯化胆固醇在人低密度脂蛋白和极低密度脂蛋白与高密度脂蛋白之间的体外转移进行了研究。从低密度脂蛋白（t1/2 = 44分钟）的转移速率比从极低密度脂蛋白（55分钟）更快。2%蛋白质的存在对转移没有影响。然而，10%白蛋白或脂蛋白缺乏血清使t1/2降低了35%，这表明血浆蛋白对未酯化胆固醇转移速率没有特异性影响。
