近交系小鼠睡眠的数量遗传学
Quantitative genetics of sleep in inbred mice.
作者信息
Tafti Mehdi
机构信息
Center for Integrative Genomics (CIG), University of Lausanne, Génopode Bldg, 1015 Dorigny-Lausanne, Switzerland.
出版信息
Dialogues Clin Neurosci. 2007;9(3):273-8. doi: 10.31887/DCNS.2007.9.3/mtafti.
Abstract
The timing and the organization of sleep architecture are mainly controlled by the circadian system, while sleep need and intensity are regulated by a homeostatic process. How independent these two systems are in regulating sleep is not well understood. In contrast to the impressive progress in the molecular genetics of circadian rhythms, little is known about the molecular basis of sleep. Nevertheless, as summarized here, phenotypic dissection of sleep into its most basic aspects can be used to identify both the single major genes and small effect quantitative trait loci involved. Although experimental models such as the mouse are more readily amenable to genetic analysis of sleep, similar approaches can be applied to humans.
摘要
睡眠结构的时间安排和组织主要由昼夜节律系统控制，而睡眠需求和强度则由一个稳态过程调节。这两个系统在调节睡眠方面的独立性如何，目前尚不清楚。与昼夜节律分子遗传学取得的显著进展相比，人们对睡眠的分子基础知之甚少。然而，如下文总结的那样，将睡眠分解为最基本的方面进行表型分析，可用于识别涉及的单个主要基因和小效应数量性状基因座。尽管诸如小鼠等实验模型更易于进行睡眠的遗传分析，但类似的方法也可应用于人类。
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