Tafti Mehdi, Maret Stéphanie, Dauvilliers Yves
Center for Integrative Genomics, University of Lausanne, 1015 Lausanne-Dorigny, Switzerland.
Ann Med. 2005;37(8):580-9. doi: 10.1080/07853890500372047.
Sleep and wakefulness are complex behaviors that are influenced by many genetic and environmental factors, which are beginning to be discovered. The contribution of genetic components to sleep disorders is also increasingly recognized as important. Point mutations in the prion protein, period 2, and the prepro-hypocretin/orexin gene have been found as the cause of a few sleep disorders but the possibility that other gene defects may contribute to the pathophysiology of major sleep disorders is worth in-depth investigations. However, single gene disorders are rare and most common disorders are complex in terms of their genetic susceptibility, environmental effects, gene-gene, and gene-environment interactions. We review here the current progress in the genetics of normal and pathological sleep.
睡眠和觉醒是受多种遗传和环境因素影响的复杂行为，这些因素正逐渐被发现。遗传因素对睡眠障碍的影响也日益被认为很重要。已发现朊病毒蛋白、周期蛋白2和前阿黑皮素原/食欲素基因中的点突变是一些睡眠障碍的病因，但其他基因缺陷可能导致主要睡眠障碍病理生理学的可能性值得深入研究。然而，单基因疾病很少见，大多数常见疾病在遗传易感性、环境影响、基因-基因和基因-环境相互作用方面都很复杂。我们在此综述正常和病理性睡眠遗传学的当前进展。
