Shaw Paul J, Franken Paul
The Neurosciences Institute, 10640 John J Hopkins Dr, San Diego, California 92121, USA.
J Neurobiol. 2003 Jan;54(1):179-202. doi: 10.1002/neu.10167.
Sleep has been identified in all mammals and nonmammalian vertebrates that have been critically evaluated. In addition, sleep-like states have also been identified and described in several invertebrates. Despite this prevalence throughout the animal kingdom, the function of sleep remains a mystery. The completion of several genome sequencing projects has led to the expectation that fundamental aspects of sleep can be elucidated through genetic dissection. Indeed, studies in both the mouse and fly have begun to reveal tantalizing suggestions about the underlying principles that regulate sleep homeostasis. In this article we will review recent studies that have used genetic techniques to evaluate sleep in the fruit fly and the mouse.
在所有经过严格评估的哺乳动物和非哺乳动物脊椎动物中都已发现睡眠现象。此外，在几种无脊椎动物中也已识别并描述了类似睡眠的状态。尽管睡眠现象在动物界普遍存在，但其功能仍然是个谜。几个基因组测序项目的完成使得人们期望能够通过基因剖析来阐明睡眠的基本方面。事实上，对小鼠和果蝇的研究已经开始揭示关于调节睡眠稳态的潜在原理的诱人线索。在本文中，我们将综述最近利用基因技术评估果蝇和小鼠睡眠的研究。
