Kung Brian, Deschenes Geoffrey R, Keane William, Cunnane Mary, Jacob-Ampuero Marie-Paule, Rosen Marc
Department of Otolaryngology--Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Ear Nose Throat J. 2007 Sep;86(9):561-4.
Malignant melanoma of the nose and paranasal sinuses can be a devastating disease, typically presenting at an advanced stage, with a 5-year survival rate ranging between 20 and 30%. It is an uncommon process, often misdiagnosed both clinically and pathologically. We present the case of an 80-year-old man who had a 2-month history of progressively worsening left-sided epistaxis and nasal obstruction. Radiographic evidence indicated the presence of soft tissue in the left maxillary sinus and nasal cavity resembling massive nasal polyposis and chronic fungal sinusitis. Magnetic resonance imaging was not performed because the patient had a pacemaker. After endoscopic debridement of the soft-tissue mass, frozen-section analysis detected no evidence of tumor. The final pathologic diagnosis was malignant melanoma. Otolaryngologists should be familiar with the difficulties inherent in the diagnosis and management of sinonasal melanomas.
鼻和鼻窦恶性黑色素瘤可能是一种灾难性疾病,通常在晚期出现,5年生存率在20%至30%之间。这是一个不常见的过程,在临床和病理上常常被误诊。我们报告一例80岁男性患者,有2个月逐渐加重的左侧鼻出血和鼻塞病史。影像学证据显示左上颌窦和鼻腔存在软组织,类似巨大鼻息肉和慢性真菌性鼻窦炎。由于患者有起搏器,未进行磁共振成像检查。在内镜下对软组织肿块进行清创后,冰冻切片分析未发现肿瘤证据。最终病理诊断为恶性黑色素瘤。耳鼻喉科医生应熟悉鼻窦黑色素瘤诊断和治疗中固有的困难。