放线菌产生的萜类化合物研究：草酸萜类化合物A、B、C、D和E，链霉菌属KO - 3988产生的二萜类化合物。

Studies on terpenoids produced by actinomycetes: oxaloterpins A, B, C, D, and E, diterpenes from Streptomyces sp. KO-3988.

作者信息

Motohashi Keiichiro, Ueno Ryoko, Sue Masayuki, Furihata Kazuo, Matsumoto Takuo, Dairi Tohru, Omura Satoshi, Seto Haruo

机构信息

Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156-8502, Japan.

出版信息

J Nat Prod. 2007 Nov;70(11):1712-7. doi: 10.1021/np070326m. Epub 2007 Oct 31.

DOI:10.1021/np070326m

PMID:17970596

Abstract

Following screening for terpenoids produced by Streptomyces sp. KO-3988, five new diterpenes named oxaloterpins A (1), B (2), C (3), D (4), and E (5) together with the known viguiepinone (6) were isolated from culture broth, and their structures were established on the basis of extensive NMR and MS analyses. The absolute configuration of oxaloterpin A was determined by the modified Mosher's method as 3 R, 5 S, 8 S, 10 R, 13 S.

摘要

在对链霉菌属KO-3988产生的萜类化合物进行筛选后，从培养液中分离出了5种新的二萜类化合物，分别命名为草酸萜A（1）、B（2）、C（3）、D（4）和E（5），以及已知的维吉平酮（6），并通过广泛的核磁共振（NMR）和质谱（MS）分析确定了它们的结构。草酸萜A的绝对构型通过改良的莫舍尔方法确定为3R、5S、8S、10R、13S。