Bogdanović R, Mikuska M, Cvorić A, Nikolić V, Sindjić M, Ognjanović M, Abinun M
Srp Arh Celok Lek. 1994 Jan-Feb;122(1-2):26-30.
Clinical and laboratory features in 27 children and adolescents (24 females, 3 males) with lupus nephritis were analysed and correlated with pathohistologic findings obtained by renal biopsy. The mean age at the onset of the disease was 12.1 +/- 1.9 (range 0.1-7.0) years. In the 30% of patients nephritis was one of the presenting features of the disease. The most frequent signs of the lupus nephritis at the time of biopsy were proteinuria (9 pts), proteinuria and haematuria (9 pts), and nephrotic syndrome (8 pts), while 7 patients showed decreased glomerular filtration rate (GFR), and hypertension was present in five. Distribution of patients according to the WHO morphologic classification of Lupus nephritis was as follows: 6 pts showed class Ib, 6 class II, 2 class III and 13 class IV. More severe renal dysfunction, manifested by nephrotic syndrome, proteinuria with haematuria, decreased GFR and hypertension was significantly associated with proliferative lupus nephritis (combined WHO classes III and IV). Nephrotic syndrome, haematuria and decreased serum C3 with significant probability predicted proliferative lupus nephritis, while decreased GFR was of borderline predictive value.
分析了27例狼疮性肾炎儿童及青少年患者（24例女性，3例男性）的临床和实验室特征，并将其与肾活检的病理组织学结果进行关联分析。疾病发作时的平均年龄为12.1±1.9（范围0.1 - 7.0）岁。30%的患者中，肾炎是疾病的首发特征之一。活检时狼疮性肾炎最常见的体征为蛋白尿（9例）、蛋白尿和血尿（9例）以及肾病综合征（8例），而7例患者肾小球滤过率（GFR）降低，5例存在高血压。根据世界卫生组织（WHO）狼疮性肾炎形态学分类，患者分布如下：6例为Ib类，6例为II类，2例为III类，13例为IV类。以肾病综合征、血尿伴蛋白尿、GFR降低和高血压为表现的更严重肾功能不全与增殖性狼疮性肾炎（WHO III类和IV类合并）显著相关。肾病综合征、血尿和血清C3降低有显著概率预测增殖性狼疮性肾炎，而GFR降低具有临界预测价值。
