Bogdanović Radovan, Nikolić Vesna, Ognjanović Milos, Dimitrijević Jovan, Marković-Lipkovski Jasmina, Pasić Srdjan, Minić Aleksandra, Stajić Natasa
Dr. Vukan Chupitsh Institute of Mother and Child Health Care of Serbia, Belgrade.
Srp Arh Celok Lek. 2002 Aug;130 Suppl 3:1-5.
In 53 children and adolescents (47 males, 6 females) with lupus nephritis, clinical features at the time of renal biopsy were analyzed and correlated with pathohistological findings. The mean age at the time of diagnosis of systemic lupus was 12.9 +/- 2.6 (SD) years; the mean ages at the time of diagnosis of lupus nephritis and renal biopsy were 13.5 +/- 2.6 and 13.6 +/- 2.5 years, respectively. The most frequent clinical and laboratory features of lupus nephritis at the time of biopsy were proteinuria (100% of patients), haematuria (88%), nephrotic syndrome (38%), hypertension (32%), and decreased glomerular filtration rate (26%). On initial biopsy, the most frequent finding was diffuse proliferative glomerulonephritis (in 64.1%), followed by "mesangiopathy" (20.8%), minimal changes (7.5%), membranous nephropathy (5.8%), and focal proliferative nephritis (1.9%). Nephrotic syndrome, hypertension, decreased glomerular filtration rate, and haematuria were significantly associated with WHO classes IV and III of lupus nephritis.
对53例狼疮性肾炎患儿及青少年（47例男性，6例女性）进行研究，分析其肾活检时的临床特征，并与病理组织学结果进行关联分析。系统性红斑狼疮诊断时的平均年龄为12.9±2.6（标准差）岁；狼疮性肾炎诊断时及肾活检时的平均年龄分别为13.5±2.6岁和13.6±2.5岁。肾活检时狼疮性肾炎最常见的临床和实验室特征为蛋白尿（100%的患者）、血尿（88%）、肾病综合征（38%）、高血压（32%）和肾小球滤过率降低（26%）。初次活检时，最常见的发现是弥漫性增殖性肾小球肾炎（64.1%），其次是“系膜病变”（20.8%）、微小病变（7.5%）、膜性肾病（5.8%）和局灶性增殖性肾炎（1.9%）。肾病综合征、高血压、肾小球滤过率降低和血尿与世界卫生组织狼疮性肾炎IV级和III级显著相关。
