Donangelo C M, Trugo N M, Mesquita V L, Rosa G, Da-Silva V L
Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Brasil.
Braz J Med Biol Res. 1991;24(9):889-93.
The objective of this study was to compare lactoferrin (LF) levels and unsaturated iron-binding capacity (UIBC) of colostrum from Brazilian women aged 20-38 years of low (N = 28) and high (N = 15) socioeconomic level. Both groups received a similar amount of supplemental iron (25-65 mg/day) during pregnancy. We also determined the relationship between LF levels and UIBC, and between these components and maternal iron status. Both groups (low and high socioeconomic level) showed adequate and similar mean hematocrit (35.0 +/- 1.3% and 35.9 +/- 1.3%, respectively) and serum ferritin (64 +/- 12 micrograms/l and 57 +/- 12 micrograms/l, respectively) levels. Furthermore, LF levels (5.7 +/- 0.9 mg/ml and 5.5 +/- 0.6 mg/ml) and UIBC (3.8 +/- 0.3 micrograms/ml and 3.1 +/- 0.3 micrograms/ml) were not significantly different in the two groups of women, nor were they related to maternal hematocrit or serum ferritin. UIBC was significantly (P = 0.009), although weakly positively correlated (r = 0.45) with LF levels, suggesting that other colostrum ligands may contribute substantially to the capacity of colostrum to bind exogenous iron.
本研究的目的是比较社会经济水平低（N = 28）和高（N = 15）的20 - 38岁巴西女性初乳中乳铁蛋白（LF）水平和不饱和铁结合能力（UIBC）。两组在孕期均接受了相似剂量的补铁（25 - 65毫克/天）。我们还确定了LF水平与UIBC之间以及这些成分与母体铁状态之间的关系。两组（低社会经济水平组和高社会经济水平组）的平均血细胞比容（分别为35.0 +/- 1.3%和35.9 +/- 1.3%）和血清铁蛋白水平（分别为64 +/- 12微克/升和57 +/- 12微克/升）均充足且相似。此外，两组女性的LF水平（5.7 +/- 0.9毫克/毫升和5.5 +/- 0.6毫克/毫升）和UIBC（3.8 +/- 0.3微克/毫升和3.1 +/- 0.3微克/毫升）无显著差异，且与母体血细胞比容或血清铁蛋白均无关联。UIBC与LF水平呈显著正相关（P = 0.009），尽管相关性较弱（r = 0.45），这表明初乳中的其他配体可能对初乳结合外源性铁的能力有很大贡献。
