Christensen R D, Jopling J, Henry E, Wiedmeier S E
Intermountain Healthcare, Ogden, UT 84403, USA.
J Perinatol. 2008 Jan;28(1):24-8. doi: 10.1038/sj.jp.7211852. Epub 2007 Nov 1.
The erythrocyte indices (mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) and mean corpuscular hemoglobin (MCH)) were originally reported using hand-calculated values, based on a centrifuge-spun hematocrit, a counting-chamber erythrocyte count and a hemoglobin concentration measured by any number of hemoglobinometry methods. Modern blood cell analyzers measure the MCV, and calculate the MCHC and MCH, on the basis of logs higher sample sizes than employed in the original methods.
With a single type of automated blood cell counter (Beckman Coulter LH 750; Fullerton, CA, USA), we determined the ranges of erythrocyte indices among neonates of 22 to 42 weeks gestation. Data were accumulated during a 3-year period from a multihospital health care system, using all indices reported on untransfused neonates during their first day of life.
Erythrocyte indices were obtained from 17,634 tests performed on 12,016 neonates. The MCV and the MCH decreased with advancing gestational age. For instance, the MCV diminished from 119+/-7 fl (mean+/-s.d.) in neonates < or =25 weeks gestation to 106+/-4 fl at 40 weeks. The MCH diminished from 40+/-2 pg in neonates < or =25 weeks gestation to 36+/-2 pg at 40 weeks. The MCHC did not change appreciably with gestational age (34+/-1 pg dl(-1)).
The results describe the expected values for erythrocyte indices on the first day of life among untransfused neonates. Additional study is needed to determine the relevance of very high or low erythrocyte indices in this population and to understand any physiological advantage of these very large erythrocytes during fetal development.
红细胞指数（平均红细胞体积（MCV）、平均红细胞血红蛋白浓度（MCHC）和平均红细胞血红蛋白（MCH））最初是基于手工计算得出的值进行报告的，这些值基于离心法测定的血细胞比容、血细胞计数板进行的红细胞计数以及通过多种血红蛋白测定方法测得的血红蛋白浓度。现代血细胞分析仪基于比原始方法更大的样本量来测量MCV，并计算MCHC和MCH。
使用单一类型的自动血细胞计数器（贝克曼库尔特LH 750；美国加利福尼亚州富勒顿），我们确定了妊娠22至42周新生儿的红细胞指数范围。在3年期间，从一个多医院医疗保健系统收集数据，使用未输血新生儿出生第一天报告的所有指数。
对12,016名新生儿进行了17,634次检测，获得了红细胞指数。MCV和MCH随着胎龄增加而降低。例如，妊娠≤25周的新生儿MCV为119±7 fl（平均值±标准差），到40周时降至106±4 fl。妊娠≤25周的新生儿MCH为40±2 pg，到40周时降至36±2 pg。MCHC随胎龄变化不明显（34±1 pg dl⁻¹）。
这些结果描述了未输血新生儿出生第一天红细胞指数的预期值。需要进一步研究以确定该人群中红细胞指数极高或极低的相关性，并了解这些非常大的红细胞在胎儿发育过程中的任何生理优势。
