Ravazio M R, Paschoalini M A
Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina, Florianópolis, Brasil.
Braz J Med Biol Res. 1991;24(9):943-6.
The effects of noradrenaline (NA) on food intake were investigated in 69 satiated (food ad libitum) adult pigeons (320-360 g). NA (30 nmol, N = 10, and 80 nmol, N = 12, in 1 microliter NaCl) was injected into the right lateral ventricle. Both doses caused a significant increase in food consumption; the higher dose caused a more prolonged effect. The 30-nmol NA injection induced significant increases in the 1st (from 1.6 to 4.5 g) and 6th (19.4 to 25.9 g) hours. The 80-nmol dose caused significant increases from the 1st to the 5th hour (1.6 to 6.8, 4.4 to 8.7, 7.1 to 10.8, 10.1 to 14.1 and 14.9 to 21.0 g). Previous intracerebroventricular administration of phentolamine (50 nmol, N = 12), but not of propranolol (100 nmol, N = 13) suppressed food ingestion increased by NA administration, with identical results to those of the control group (N = 22). These results indicate that central adrenergic synapses are likely to be involved in the mediation of food intake regulation.
在69只饱足（自由进食）的成年鸽子（320 - 360克）中研究了去甲肾上腺素（NA）对食物摄入的影响。将NA（30纳摩尔，N = 10，以及80纳摩尔，N = 12，溶于1微升氯化钠）注入右侧脑室。两种剂量均导致食物消耗显著增加；较高剂量产生的作用持续时间更长。注射30纳摩尔NA在第1小时（从1.6克增至4.5克）和第6小时（从19.4克增至25.9克）引起显著增加。80纳摩尔剂量在第1至第5小时引起显著增加（从1.6克增至6.8克、从4.4克增至8.7克、从7.1克增至10.8克、从10.1克增至14.1克以及从14.9克增至21.0克）。预先脑室内注射酚妥拉明（50纳摩尔，N = 12）而非普萘洛尔（100纳摩尔，N = 13）可抑制由NA给药引起的食物摄取增加，结果与对照组（N = 22）相同。这些结果表明，中枢肾上腺素能突触可能参与食物摄入调节的介导过程。
