下丘脑内酚妥拉明对家鸽外周去甲肾上腺素所致体温过低的影响。
Effect of intrahypothalamic phentolamine on hypothermia produced by peripheral noradrenaline in the pigeon.
作者信息
Hissa R, Pyörnilä A
出版信息
Br J Pharmacol. 1977 Oct;61(2):163-6. doi: 10.1111/j.1476-5381.1977.tb08400.x.
Abstract
1 The effect of intrahypothalamic phentolamine (1 and 1 microliter of a 10 microgram/microliter solution) on hypothermia induced by intramuscular injection of noradrenaline (NA, 2 mg/kg) at different times (2, 10, 20 min) after phentolamine was investigated in pigeons. 2 Administration of phentolamine shortly before NA was shown to attenuate hypothermic responses to NA. 3 It is suggested that the attenuation is due to blockade of central hypothermic effects of intramuscular NA. 4 The mapping of injection sites in the brains was carried out.
摘要
1 研究了在鸽子体内，下丘脑内注射酚妥拉明（1微升和1微升10微克/微升溶液）对在酚妥拉明注射后不同时间（2、10、20分钟）肌肉注射去甲肾上腺素（NA，2毫克/千克）所诱导的体温过低的影响。2 结果显示，在NA注射前不久给予酚妥拉明可减弱对NA的体温过低反应。3 提示这种减弱是由于阻断了肌肉注射NA的中枢性体温过低效应。4 进行了大脑注射部位的定位。
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本文引用的文献
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Br J Pharmacol Chemother. 1967 Sep;31(1):152-61. doi: 10.1111/j.1476-5381.1967.tb01985.x.
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Br J Pharmacol. 1969 May;36(1):195P-197P.
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J Physiol. 1968 May;196(2):116P-117P.
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Acta Pharmacol Toxicol (Copenh). 1967;25(4):447-55. doi: 10.1111/j.1600-0773.1967.tb00413.x.
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