Hissa R, Pyörnilä A
Br J Pharmacol. 1977 Oct;61(2):163-6. doi: 10.1111/j.1476-5381.1977.tb08400.x.
1 The effect of intrahypothalamic phentolamine (1 and 1 microliter of a 10 microgram/microliter solution) on hypothermia induced by intramuscular injection of noradrenaline (NA, 2 mg/kg) at different times (2, 10, 20 min) after phentolamine was investigated in pigeons. 2 Administration of phentolamine shortly before NA was shown to attenuate hypothermic responses to NA. 3 It is suggested that the attenuation is due to blockade of central hypothermic effects of intramuscular NA. 4 The mapping of injection sites in the brains was carried out.
1 研究了在鸽子体内,下丘脑内注射酚妥拉明(1微升和1微升10微克/微升溶液)对在酚妥拉明注射后不同时间(2、10、20分钟)肌肉注射去甲肾上腺素(NA,2毫克/千克)所诱导的体温过低的影响。2 结果显示,在NA注射前不久给予酚妥拉明可减弱对NA的体温过低反应。3 提示这种减弱是由于阻断了肌肉注射NA的中枢性体温过低效应。4 进行了大脑注射部位的定位。