Barker-Collo Suzanne, Feigin Valery L, Dudley Margaret
Department of Psychology, Faculty of Science, The University of Auckland, Auckland, New Zealand.
N Z Med J. 2007 Oct 26;120(1264):U2780.
A significant proportion of stroke survivors suffer from persistent and significant fatigue which is linked to reduced independence and case fatality. Despite its high prevalence and detrimental effects, studies of post-stroke fatigue (PSF) interventions are scarce. Only one randomised controlled trial of post-stroke fatigue treatment (i.e. fluoxetine) was identified, and though improving post-stroke emotional incontinence and depression in patients with fatigue this did not improve PSF itself. Despite there being no literature on its efficacy, patient and family education/counselling has been identified as an important rehabilitation intervention for the management of stroke-related fatigue, which has been found effective in other patient groups (i.e. cancer, multiple sclerosis, and those with traumatic brain injury). Factors contributing to the lack of evidence for PSF management are identified and it is concluded that there is a need to better differentiate those most likely to suffer PSF, to validate existing assessments of fatigue, and to evaluate the efficacy of fatigue management and treatment strategies in stroke survivors.
相当一部分中风幸存者患有持续且严重的疲劳，这与独立性降低和病死率相关。尽管中风后疲劳（PSF）患病率高且有不良影响，但针对其干预措施的研究却很少。仅发现一项关于中风后疲劳治疗（即氟西汀）的随机对照试验，虽然该试验改善了疲劳患者的中风后情感失禁和抑郁症状，但并未改善PSF本身。尽管尚无关于其疗效的文献，但患者及家属教育/咨询已被确定为管理中风相关疲劳的重要康复干预措施，且已发现在其他患者群体（即癌症、多发性硬化症和创伤性脑损伤患者）中有效。确定了导致PSF管理缺乏证据的因素，并得出结论，有必要更好地区分最有可能患PSF的人群，验证现有的疲劳评估方法，并评估中风幸存者疲劳管理和治疗策略的疗效。
