Kanodia Shreya, Da Silva Diane M, Kast W Martin
Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.
Int J Cancer. 2008 Jan 15;122(2):247-59. doi: 10.1002/ijc.23252.
Human papillomavirus (HPV)-induced lesions are distinct in that they have targetable foreign antigens, the expression of which is necessary to maintain the cancerous phenotype. Hence, they pose as a very attractive target for "proof of concept" studies in the development of therapeutic vaccines. This review will focus on the most recent clinical trials for the immunotherapy of mucosal and cutaneous HPV-induced lesions as well as emerging therapeutic strategies that have been tested in preclinical models for HPV-induced lesions. Progress in peptide-based vaccines, DNA-based vaccines, viral/bacterial vector-based vaccines, immune response modifiers, photodynamic therapy and T cell receptor based therapy for HPV will be discussed.
人乳头瘤病毒(HPV)诱导的病变具有独特之处,即它们具有可靶向的外来抗原,其表达对于维持癌性表型是必需的。因此,它们成为治疗性疫苗开发中“概念验证”研究非常有吸引力的靶点。本综述将聚焦于黏膜和皮肤HPV诱导病变免疫治疗的最新临床试验,以及在HPV诱导病变的临床前模型中已测试的新兴治疗策略。还将讨论基于肽的疫苗、基于DNA的疫苗、基于病毒/细菌载体的疫苗、免疫反应调节剂、光动力疗法和基于T细胞受体的HPV治疗方法的进展。