Sun Ping, Krishnan Arthi, Yadav Abhishek, Singh Shreeyukta, MacDonnell Frederick M, Armstrong Daniel W
Department of Chemistry and Biochemistry, The University of Texas at Arlington, Texas 76019, USA.
Inorg Chem. 2007 Nov 26;46(24):10312-20. doi: 10.1021/ic701023x. Epub 2007 Oct 31.
Rapid, highly efficient, analytical resolution of the enantiomers of eight different monomeric ruthenium(II) polypyridyl complexes has been achieved using HPLC with cyclodextrin chiral stationary phases. This technique also proved capable of separating both of the diastereomers and the enantiomers of one dinuclear complex in a single run, whereas similar efforts with another dinuclear complex gave only one stereoisomer cleanly. Factors such as the stereochemistry of the chiral selectors, solvent polarity, and salt effects can be altered to provide precise control of the enantioselective interactions. The ability to quickly and quantitatively determine the enantiopurity of a given ruthenium complex allowed facile reexamination and optimization of the commonly used bulk resolution procedures based on diastereomeric coprecipitation with sodium arsenyl (+)-tartrate or sodium arsenyl (-)-tartrate salts.
使用具有环糊精手性固定相的高效液相色谱法，已实现了对八种不同单体钌（II）多吡啶配合物对映体的快速、高效分析拆分。该技术还证明能够在一次运行中分离一种双核配合物的非对映异构体和对映异构体，而对另一种双核配合物进行类似操作时，仅能清晰地得到一种立体异构体。可以改变手性选择剂的立体化学、溶剂极性和盐效应等因素，以精确控制对映选择性相互作用。能够快速、定量地测定给定钌配合物的对映体纯度，这使得基于与（+）-酒石酸亚砷酸钠或（-）-酒石酸亚砷酸钠盐进行非对映共沉淀的常用本体拆分程序得以轻松重新审视和优化。
