Sun Ping, Krishnan Arthi, Yadav Abhishek, MacDonnell Frederick M, Armstrong Daniel W
Department of Chemistry and Biochemistry, The University of Texas at Arlington, TX 76019, USA.
J Mol Struct. 2008 Nov 12;890(1-3):75-80. doi: 10.1016/j.molstruc.2008.02.030.
A high performance liquid chromatographic method using macrocyclic glycopeptide chiral stationary phases (CSPs) was used to separate enantiomers of seven ruthenium(II) polypyridyl complexes. Among the five different CSPs, the Chirobiotic T2 was most effective and baseline separated all complexes. All complexes show the same elution order with the Δ-enantiomer being retained longer than the Λ-enantiomer. The mobile phase composition, including organic modifier type, organic modifier percent, salt type, and salt concentration, produced significant effects on the enantioresolution.
采用使用大环糖肽手性固定相（CSPs）的高效液相色谱法分离七种钌（II）多吡啶配合物的对映体。在五种不同的CSPs中，Chirobiotic T2最有效，能实现所有配合物的基线分离。所有配合物都呈现相同的洗脱顺序，Δ-对映体的保留时间比Λ-对映体更长。流动相组成，包括有机改性剂类型、有机改性剂百分比、盐类型和盐浓度，对映体拆分产生显著影响。
