Racle J P, Kusiewicz R, Gaudray A, Gantheret O, Benkhadra A
Service d'anesthésiologie, Centre Hospitalier général, Chalon-sur Saône.
Cah Anesthesiol. 1991;39(7):475-9.
The effects of metaraminol on the duration of plain bupivacaine spinal anaesthesia were investigated in a double-blind study of 80 elderly patients. Each patient received a basic solution of 0.5% plain bupivacaine to which was added either physiological saline, or 1 mg, 2 mg or 3 mg metaraminol. There were no significant differences between the four groups in the mean time from injection to recovery from analgesia in the two and four uppermost segments. However the addition of metaraminol increased the mean durations of analgesia at the L2 level and of the motor block. It is concluded that, in an attempt to prolong plain bupivacaine spinal anaesthesia in the uppermost segments, addition of metaraminol does not appear to be justified.
在一项针对80名老年患者的双盲研究中,研究了间羟胺对单纯布比卡因脊麻持续时间的影响。每位患者接受0.5%单纯布比卡因的基础溶液,其中分别添加生理盐水、1毫克、2毫克或3毫克间羟胺。四组在注射至两个最上段和四个最上段镇痛恢复的平均时间上无显著差异。然而,添加间羟胺增加了L2水平的平均镇痛持续时间和运动阻滞的平均持续时间。得出的结论是,为了延长最上段的单纯布比卡因脊麻时间,添加间羟胺似乎没有依据。