Classon B, Garegg P J, Oscarson S, Tidén A K
Department of Organic Chemistry, Arrhenius Laboratory, University of Stockholm, Sweden.
Carbohydr Res. 1991 Sep 2;216:187-96. doi: 10.1016/0008-6215(92)84161-k.
The synthesis is described of p-nitrophenyl 2-acetamido-3-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta -D- mannopyranosiduronic acid, corresponding to the disaccharide repeating unit of the capsular polysaccharide of Haemophilus influenzae type d, which, after conversion of the p-nitro- into a p-amino-phenyl residue, may be attached to a protein to make an artificial antigen for immunological studies. The synthesis incorporates a facile route to the 2-acetamido-2-deoxy-beta-D-mannopyranosyl unit.
描述了对硝基苯基 2-乙酰氨基-3-O-(2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基)-2-脱氧-β-D-甘露吡喃糖醛酸的合成，其对应于d型流感嗜血杆菌荚膜多糖的二糖重复单元，在将对硝基转化为对氨基苯基残基后，可连接到蛋白质上以制备用于免疫学研究的人工抗原。该合成包含了一条通往2-乙酰氨基-2-脱氧-β-D-甘露吡喃糖基单元的简便路线。
