Taylor Nicole R, Zele Andrew J, Vingrys Algis J, Stanley Robin G
Department of Optometry & Vision Sciences, University of Melbourne, Parkville, Australia.
Vet Ophthalmol. 2007 Nov-Dec;10 Suppl 1:8-11. doi: 10.1111/j.1463-5224.2007.00485.x.
To record intraocular pressure (IOP) of three different dog breeds following administration of one drop of 1% tropicamide.
Three dog breeds -- Golden Retrievers (n = 20), Siberian Huskies (n = 20) and English Cocker Spaniels (n = 36) -- were studied.
IOPs were measured using a Tonopen following corneal anesthesia with a single drop of 0.5% proxymetacaine. A drop of 0.5% tropicamide was then administered bilaterally and a second IOP measurement was taken 30 min later (postdilation). The difference between the two measurements was considered as the effect of mydriasis on IOP.
Dogs had an average IOP of 14.9 +/- 3.2 mmHg, with 95% confidence limits ranging from 8 to 22 mmHg. There were significant differences between breeds (P < 0.006) with Siberian Huskies having higher IOPs (17.2 +/- 3.7 mmHg) than the other breeds (Spaniels: 14.2 +/- 2.8 mmHg, P < 0.01; Retrievers: 14 +/- 1.9 mmHg, P < 0.001). The majority (60%) of dogs displayed 5 mmHg or less in IOP change postmydriasis. Siberian Huskies showed the highest IOP levels, and also had the greatest variability with dilation.
Interbreed variability in effect of tropicamide of canine IOP is evident.
记录滴入一滴1%托吡卡胺后三种不同犬种的眼压（IOP）。
研究了三种犬种——金毛寻回犬（n = 20）、西伯利亚哈士奇（n = 20）和英国可卡犬（n = 36）。
用一滴0.5%丙美卡因进行角膜麻醉后，使用眼压计测量眼压。然后双侧滴入一滴0.5%托吡卡胺，30分钟后（散瞳后）再次测量眼压。两次测量的差值被视为散瞳对眼压的影响。
犬的平均眼压为14.9±3.2 mmHg，95%置信区间为8至22 mmHg。不同犬种之间存在显著差异（P < 0.006），西伯利亚哈士奇的眼压（17.2±3.7 mmHg）高于其他犬种（可卡犬：14.2±2.8 mmHg，P < 0.01；金毛寻回犬：14±1.9 mmHg，P < 0.001）。大多数（60%）犬散瞳后眼压变化为5 mmHg或更低。西伯利亚哈士奇眼压水平最高，散瞳后的变异性也最大。
托吡卡胺对犬眼压的影响存在品种间差异，这一点很明显。
