de Zwart-Storm Eugene A, van Marion Ariënne M W, Gorter Simone L, Frank Jorge, Kelleners-Smeets Nicole W J
Department of Dermatology, University Hospital Maastricht, The Netherlands.
Int J Dermatol. 2007 Nov;46 Suppl 3:39-41. doi: 10.1111/j.1365-4632.2007.03511.x.
A 64-year-old woman developed slowly expanding asymptomatic red bumps on the hands and in the face since 1 year. Histopathological examination showed mononucleated and multinucleated giant cells with a characteristic "ground glass" appearance. Based on the clinical and histopathological findings, we made the diagnosis of multicentric reticulohistiocytosis (MRH). This rare variant of histiocytosis was described for the first time in 1950. Clinically, the disorder is characterized by papulonodular cutaneous lesions, and a severe and often destructive arthropathy. The reticulohistiocytoses are a rare group of closely related non-Langerhans cell histiocytosis that most commonly manifest in adults. Because MRH can be associated with an underlying malignancies, and an interdisciplinary examination and regimen of these patients is advisable.
一名64岁女性自1年前起双手和面部出现缓慢扩大的无症状红色丘疹。组织病理学检查显示单核和多核巨细胞，具有特征性的“毛玻璃”外观。根据临床和组织病理学表现，我们诊断为多中心网状组织细胞增多症（MRH）。这种罕见的组织细胞增多症变体于1950年首次被描述。临床上，该疾病的特征是丘疹结节性皮肤病变以及严重且常具破坏性的关节病。网状组织细胞增多症是一组罕见的、密切相关的非朗格汉斯细胞组织细胞增多症，最常见于成年人。由于MRH可能与潜在恶性肿瘤相关，因此对这些患者进行跨学科检查和治疗方案是可取的。
