[阻塞性肺部疾病患儿血清中免疫球蛋白和α-1抗胰蛋白酶的变化浓度]
[The change concentrations in the serum of immunoglobulins and alpha-1 atitrypsin in children with obstructive pulmonary diseases].
作者信息
Miljković D, Dzelebcjić J, Kostić N
出版信息
Srp Arh Celok Lek. 1995 May-Jun;123(5-6):116-9.
Total concentrations of IgA, IgM, IgG, IgE and alpha-antitypsin were determined in the sera of 50 children of different age with bronchial asthma and obstructive bronchitis and 20 healthy children as control group. By using radial immunodifusion method the total IgA, IgM, IgG and alpha-antitrypsin were determined. Significantly higher values of IgE (t=5.17; p<0.01) and alpha-1 antitrypsin (t=4.6; p<0.01) were found in group of seek children. No significant difference in concentrations of IgA, IgM and IgG. Higher values of IgE and alpha-antitrypsin suggesting their pathophysiologic significance in airway obstruction infection in children with chronic obstructive pulmonary diseases.
测定了50例不同年龄患支气管哮喘和阻塞性支气管炎的儿童以及20例作为对照组的健康儿童血清中IgA、IgM、IgG、IgE和α-抗胰蛋白酶的总浓度。采用放射免疫扩散法测定总IgA、IgM、IgG和α-抗胰蛋白酶。在患病儿童组中发现IgE（t = 5.17；p < 0.01）和α-1抗胰蛋白酶（t = 4.6；p < 0.01）的值显著更高。IgA、IgM和IgG的浓度无显著差异。IgE和α-抗胰蛋白酶的值较高，提示它们在慢性阻塞性肺疾病患儿气道阻塞感染中的病理生理意义。
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