Carise Deni, Dugosh Karen Leggett, McLellan A Thomas, Camilleri Amy, Woody George E, Lynch Kevin G
Treatment Systems Section, Treatment Research Institute, 600 Public Ledger Building, 150 South Independence Mall West, Philadelphia, PA 19106-3475, USA.
Am J Psychiatry. 2007 Nov;164(11):1750-6. doi: 10.1176/appi.ajp.2007.07050252.
OxyContin and other pharmaceutical opioids have been given special attention in the media, who frequently describe problematic users of the drug as previously drug-naive individuals who become addicted following legitimate prescriptions for medical reasons. The purpose of this study was to characterize the nature and origins of pharmaceutical opioid addiction among patients presenting at substance abuse treatment programs.
The authors evaluated the prevalence and correlates of OxyContin use and abuse among a population of 27,816 subjects admitted to 157 addiction treatment programs in the United States from 2001-2004. The data collected included the lifetime and past 30-day use of OxyContin and other drugs prior to admission to addiction treatment, source of drug supply, and prior treatment history.
Approximately 5% of all subjects who were admitted to the 157 addiction treatment programs reported prior use of OxyContin. Of those subjects, 4.5% reported using the drug on a regular basis for at least 1 year, and 2% reported use of the drug during the 30 days prior to admission. Seventy-eight percent of subjects who reported OxyContin use also reported that the drug had not been prescribed to them for any medical reason, 86% reported use of the drug to "get high or get a buzz," and 78% reported receiving prior treatment for a substance use disorder.
The patients in this sample did not include individuals from private therapists or pain clinics. However, among treatment-seeking individuals who use OxyContin, the drug is most frequently obtained from nonmedical sources as part of a broader and longer-term pattern of multiple substance abuse.
奥施康定及其他药用阿片类药物在媒体上受到了特别关注,媒体经常将该药物的问题使用者描述为以前未接触过毒品的人,他们因医疗原因接受合法处方后成瘾。本研究的目的是描述在药物滥用治疗项目中就诊的患者中,药用阿片类药物成瘾的性质和来源。
作者评估了2001年至2004年期间在美国157个成瘾治疗项目中收治的27816名受试者中奥施康定使用和滥用的患病率及相关因素。收集的数据包括入院接受成瘾治疗前奥施康定及其他药物的终生使用情况和过去30天的使用情况、药物供应来源以及既往治疗史。
在157个成瘾治疗项目收治的所有受试者中,约5%报告曾使用过奥施康定。在这些受试者中,4.5%报告至少连续1年定期使用该药物,2%报告在入院前30天内使用过该药物。报告使用奥施康定的受试者中,78%还报告该药物未曾因任何医疗原因开给他们,86%报告使用该药物是为了“寻求快感或兴奋”,78%报告曾接受过物质使用障碍的治疗。
本样本中的患者不包括来自私人治疗师或疼痛诊所的个体。然而,在寻求治疗的使用奥施康定的个体中,该药物最常从非医疗来源获得,是更广泛、更长期的多种物质滥用模式的一部分。