对从犬中耳炎分离出的铜绿假单胞菌进行所选氟喹诺酮类药物的抗菌测试。
Antimicrobial testing of selected fluoroquinolones against Pseudomonas aeruginosa isolated from canine otitis.
作者信息
McKay Lindsay, Rose Crystal D Schuman, Matousek Jennifer L, Schmeitzel Lynn S, Gibson Nicole M, Gaskin Jack M
机构信息
Department of Dermatology, VCA-Aurora Animal Hospital, 2600 West Galena Boulevard, Aurora, Illinois 60506, USA.
出版信息
J Am Anim Hosp Assoc. 2007 Nov-Dec;43(6):307-12. doi: 10.5326/0430307.
A total of 100 Pseudomonas aeruginosa (P. aeruginosa) isolates were collected over a 1.5-year period from cases of canine otitis. Sensitivities to enrofloxacin, marbofloxacin, and orbifloxacin were determined using minimum inhibitory concentration testing (MICT). Isolates were also tested for sensitivities to enrofloxacin and marbofloxacin using disk-diffusion susceptibility testing (DDST). Isolates were significantly more sensitive to marbofloxacin than to enrofloxacin (z = -4.57; P<0.05) or orbifloxacin (z = -5.02; P<0.05). Agreement was 87% between MICT and DDST for marbofloxacin, with approximately equal numbers of overestimation and underestimation errors. Agreement was 74% between MICT and DDST for enrofloxacin, but DDST tended to overestimate the number of enrofloxacin-susceptible strains. These results suggest that marbofloxacin is more effective against P. aeruginosa than either enrofloxacin or orbifloxacin and that relying on DDST may lead to ineffective enrofloxacin treatment.
在1.5年的时间里，从犬中耳炎病例中总共收集了100株铜绿假单胞菌。使用最低抑菌浓度测试（MICT）来测定对恩诺沙星、马波沙星和奥比沙星的敏感性。还使用纸片扩散药敏试验（DDST）对分离株进行了对恩诺沙星和马波沙星的敏感性测试。分离株对马波沙星的敏感性明显高于恩诺沙星（z = -4.57；P<0.05）或奥比沙星（z = -5.02；P<0.05）。马波沙星的MICT和DDST之间的一致性为87%，高估和低估误差的数量大致相等。恩诺沙星的MICT和DDST之间的一致性为74%，但DDST往往高估了恩诺沙星敏感菌株的数量。这些结果表明，马波沙星对铜绿假单胞菌比恩诺沙星或奥比沙星更有效，并且依赖DDST可能导致恩诺沙星治疗无效。
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