Pérgola P E, Alper R H
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66103.
Eur J Pharmacol. 1991 Oct 2;203(1):145-8. doi: 10.1016/0014-2999(91)90805-z.
The present study was to investigate the role of '5-HT2-like' receptors in the circumventricular organs in the pressor response elicited by the central injection of serotonin (5-HT) to conscious rats. The increase in blood pressure induced by intracerebroventricular (i.c.v.) 5-HT (2.5 micrograms) was attenuated by intravenous pretreatment will, the peripheral 5-HT2 antagonist xylamidine (100 or 300 micrograms/kg). A combination of xylamidine with prazosin or a V1-vasopressin antagonist did not produce a further attenuation in the pressor response. Our data suggest that when administered i.c.v., 5-HT increases blood pressure by acting on 5-HT2-like receptors located in circumventricular organs as well as areas of the brain protected by the blood-brain barrier.
本研究旨在探讨“5-羟色胺2样”受体在室周器官中对清醒大鼠中枢注射5-羟色胺（5-HT）所引发的升压反应中的作用。静脉内预先给予外周5-HT2拮抗剂赛拉米定（100或300微克/千克）可减弱脑室内（i.c.v.）注射5-HT（2.5微克）所诱导的血压升高。赛拉米定与哌唑嗪或V1-血管加压素拮抗剂联合使用并未进一步减弱升压反应。我们的数据表明，当脑室内给药时，5-HT通过作用于位于室周器官以及血脑屏障所保护的脑区中的5-HT2样受体来升高血压。
