Kushiro T, Kurumatani H, Ishii T, Yokoyama H, Koike J, Hatayama Y, Kobayashi Y, Kajiwara N
Dept. of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan.
Clin Exp Hypertens A. 1988;10 Suppl 1:339-45. doi: 10.3109/10641968809075988.
To investigate the role of the serotonergic nervous system in blood pressure regulation, 5 micrograms of 5-hydroxytryptamine (5-HT) was given i.c.v. before and after 1 microgram of i.c.v. xylamidine or 200 micrograms of i.c.v. ketanserin or 200 micrograms of i.v. ketanserin in conscious Wistar Kyoto rats. Also i.v. (0.5, 1, 2 micrograms) or i.c.v. (1 microgram) phenylephrine (PHE) were given before and after 1 microgram of i.c.v. xylamidine. I.c.v. 5-HT elicited a consistent pressor response of approximately 27mmHg and slight decrease in heart rate. MAP and heart rate did not change after xylamidine or ketanserin. Whereas pressor response to i.c.v. 5-HT after i.c.v. ketanserin or i.c.v. xylamidine was suppressed, it did not change after i.v. ketanserin. Neither i.c.v. nor i.v. PHE-induced pressor response was influenced by i.c.v. xylamidine pretreatment. These data suggest that the central 5-HT2 receptor may subserve pressor function in rats.
为研究血清素能神经系统在血压调节中的作用，在清醒的Wistar Kyoto大鼠中，于脑室内注射1微克赛拉米定或200微克酮色林或静脉注射200微克酮色林之前及之后，脑室内注射5微克5-羟色胺（5-HT）。另外，在脑室内注射1微克赛拉米定之前及之后，静脉注射（0.5、1、2微克）或脑室内注射（1微克）去氧肾上腺素（PHE）。脑室内注射5-HT可引起约27mmHg的持续升压反应及心率略有下降。赛拉米定或酮色林注射后平均动脉压（MAP）和心率未发生变化。虽然脑室内注射酮色林或赛拉米定后，对脑室内注射5-HT的升压反应受到抑制，但静脉注射酮色林后该反应未改变。脑室内或静脉注射PHE诱导的升压反应均不受脑室内注射赛拉米定预处理的影响。这些数据表明，中枢5-HT2受体可能在大鼠中发挥升压功能。
