一种合成非外消旋反式环氧化合物的通用方法：含反式环氧化合物的昆虫性信息素的简洁合成。

A general method for the synthesis of nonracemic trans-epoxides: concise syntheses of trans-epoxide-containing insect sex pheromones.

作者信息

Kang Baldip, Britton Robert

机构信息

Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, V5A 1S6, Canada.

出版信息

Org Lett. 2007 Nov 22;9(24):5083-6. doi: 10.1021/ol702273n. Epub 2007 Nov 2.

DOI:10.1021/ol702273n

PMID:17975920

Abstract

A general method for the synthesis of chiral nonracemic trans-epoxides has been developed that provides rapid access to alkyl-, alkenyl-, alkynyl-, and phenyl-substituted trans-epoxides from aldehydes. This methodology has also been applied in concise and high-yielding syntheses of both trans-epoxide containing insect sex pheromones.

摘要

已开发出一种合成手性非外消旋反式环氧化物的通用方法，该方法可从醛快速制备烷基、烯基、炔基和苯基取代的反式环氧化物。此方法还已应用于两种含反式环氧化物的昆虫性信息素的简洁且高产率的合成中。