由环氧酰胺立体选择性合成大环内酯类抗生素。链黑菌素U聚丙酸酯链的合成。

Stereoselective synthesis of macrolide-type antibiotics from epoxy amides. Synthesis of the polypropionate chain of streptovaricin u.

作者信息

Sarabia Francisco, Sánchez-Ruiz Antonio, Martín-Ortiz Laura, García-Castro Miguel, Chammaa Samy

机构信息

Department of Biochemistry, Molecular Biology and Organic Chemistry, Faculty of Sciences, University of Malaga, Campus de Teatinos s/n, 29071 Malaga, Spain.

出版信息

Org Lett. 2007 Nov 22;9(24):5091-4. doi: 10.1021/ol7022938. Epub 2007 Nov 2.

DOI:10.1021/ol7022938

PMID:17975922

Abstract

The synthesis of the polypropionate chain of Streptovaricin U (1) is described utilizing a new approach for the stereoselective synthesis of the macrolide-type antibiotics via sulfur ylides.

摘要

描述了利用一种通过硫叶立德立体选择性合成大环内酯类抗生素的新方法来合成链黑菌素U（1）的聚丙酸酯链。