Moya-Utrera Federico, Cheng-Sánchez Iván, Fuentes-Pino Irama, Sánchez-Ruiz Antonio, Sarabia Francisco
Department of Organic Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain.
Faculty of Pharmacy, University of Castilla-La Mancha, Campus de Albacete, Avda. Dr. José María Sánchez Ibáñez S/N, 02008 Albacete, Spain.
Mar Drugs. 2025 Jan 21;23(2):51. doi: 10.3390/md23020051.
A novel class of chiral sulfonium salts, derived from L- and D-methionine, was designed and successfully employed for the diastereoselective synthesis of epoxy amides. This new methodology of asymmetric epoxidation was exploited for the stereoselective construction of fused polycyclic ethers, which are structural motifs present in a great variety of natural products of marine origin. This methodology proved to be useful for the synthesis of the tricyclic system contained in yessotoxin and adriatoxin, and also in many other related natural products of marine origin belonging to the fused polycyclic ether toxins.
设计了一类新型的源自L-和D-蛋氨酸的手性锍盐，并成功用于环氧酰胺的非对映选择性合成。这种不对称环氧化的新方法被用于立体选择性构建稠合多环醚，稠合多环醚是多种海洋来源天然产物中存在的结构基序。该方法被证明可用于合成岩沙海葵毒素和阿德里亚毒素中所含的三环体系，以及许多其他属于稠合多环醚毒素的海洋来源相关天然产物。
