聚酮化合物合成中的第4族金属：一种合成源自聚丙酸酯的（E,E）-三取代1,3-二烯的汇聚策略。
Group 4 metals in polyketide synthesis: a convergent strategy for the synthesis of polypropionate-derived (E,E)-trisubstituted 1,3-dienes.
作者信息
Shimp Heidi L, Micalizio Glenn C
机构信息
Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
出版信息
Org Lett. 2005 Oct 27;7(22):5111-4. doi: 10.1021/ol052241n.
PMID:16235970
Abstract
[reaction: see text] A convergent Group 4 metal-mediated coupling process is described for the synthesis of polypropionate-derived (E,E)-1,3-dienes. Both the stereochemistry of the internal alkyne and the presence/absence of a tethered alkoxide on this pi-component were found to play critical roles in dictating the regiochemical course of these reactions.
摘要
[反应：见正文] 描述了一种用于合成聚丙酸酯衍生的（E，E）-1,3-二烯的第4族金属介导的收敛偶联过程。发现内炔的立体化学以及该π-组分上连接的醇盐的存在与否在决定这些反应的区域化学过程中起着关键作用。
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