Bagga A, Kabra S K, Srivastava R N, Bhuyan U N
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi.
Indian Pediatr. 1991 Oct;28(10):1153-7.
In order to evaluate clinical features and renal pathological findings of Henoch-Schonlein syndrome (HSS) in northern Indian Children, we studied 47 such cases. The mean age at onset was 8.5 yr; sex ratio (M:F) 2.6:1. The clinical features were purpuric rash (96%), abdominal pain (64%), Henoch-Schonlein nephritis (51%) and arthralgias (47%). Patients younger than 6 yr also showed urticarial rash or edema of scalp and extremities. Henoch-Schonlein nephritis (HSN) and abdominal symptoms were more common in older cases. The manifestations of HSN were asymptomatic hematuria and/or proteinuria (n = 15), acute nephritic syndrome (n = 6), and nephrotic syndrome (n = 3). The severity of clinical manifestations correlated with the renal pathologic findings. On follow up, 29% cases showed renal impairment. The prognosis was poor in patients with the acute nephritic or nephrotic syndrome and crescents in more than 50% glomeruli. Combination of clinical data and renal biopsy findings are important in assessing the long-term outcome in cases with HSN.
为评估印度北部儿童过敏性紫癜（HSS）的临床特征和肾脏病理表现，我们研究了47例此类病例。发病的平均年龄为8.5岁；性别比（男：女）为2.6：1。临床特征为紫癜性皮疹（96%）、腹痛（64%）、过敏性紫癜肾炎（51%）和关节痛（47%）。6岁以下的患者还出现了荨麻疹样皮疹或头皮及四肢水肿。过敏性紫癜肾炎（HSN）和腹部症状在年龄较大的病例中更为常见。HSN的表现为无症状血尿和/或蛋白尿（n = 15）、急性肾炎综合征（n = 6）和肾病综合征（n = 3）。临床表现的严重程度与肾脏病理表现相关。随访时，29%的病例出现肾功能损害。急性肾炎或肾病综合征且超过50%肾小球有新月体形成的患者预后较差。临床数据和肾活检结果相结合对于评估HSN病例的长期预后很重要。
