Wilhelm-Bals Alexandra, Chehade Hassib, Girardin Eric
Unité romande de néphrologie pediatrique, Département de I'enfant et de l'adolescent, HUG, 1211 Geneve 14.
Rev Med Suisse. 2011 Feb 23;7(283):442-6.
Henoch-Schönlein purpura is a well known paediatric disease characterized by the classic triad: purpura, arthritis and abdominal pain. Short term prognosis is excellent and is mostly dependant on abdominal complications. Long term morbidity depends essentially on the severity of renal involvement which occurs in 35% of cases. Microhematuria and light proteinuria are the only signs in 80% of cases. The remaining 20% presents with nephrotic or nephritic syndrome and acute renal insufficiency. Among patients with Henoch-Schönlein nephritis the risk of developing renal insufficiency varies between 11-30% of cases. Currently, the follow up guidelines are multiple and the optimal treatment of nephritis is controversial; this is what this article proposes to discuss.
过敏性紫癜是一种广为人知的儿科疾病，其特征为典型的三联征：紫癜、关节炎和腹痛。短期预后良好，主要取决于腹部并发症。长期发病率主要取决于肾脏受累的严重程度，35%的病例会出现这种情况。80%的病例仅有镜下血尿和轻度蛋白尿这两个症状。其余20%的病例表现为肾病综合征或肾炎综合征以及急性肾功能不全。在过敏性紫癜肾炎患者中，发生肾功能不全的风险在11%至30%的病例之间有所不同。目前，随访指南多种多样，肾炎的最佳治疗方法存在争议；本文旨在讨论这一问题。
