Mondelli Melina, Bruné Verónica, Borthagaray Graciela, Ellena Javier, Nascimento Otaciro R, Leite Clarice Q, Batista Alzir A, Torre María H
Química Inorgánica, DEC, Facultad de Química, UDELAR, Gral. Flores 2124, Montevideo, Uruguay.
J Inorg Biochem. 2008 Feb;102(2):285-92. doi: 10.1016/j.jinorgbio.2007.09.001. Epub 2007 Sep 26.
The synthesis, structural characterization, voltammetric experiments and antibacterial activity of [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O and [Ni(sulfapyridine)(2)] were studied and compared with similar previously reported copper complexes. [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O crystallized in a monoclinic system, space group C2/c where the nickel ion was in a slightly distorted octahedral environment, coordinated with two sulfisoxazole molecules through the heterocyclic nitrogen and four water molecules. [Ni(sulfapyridine)(2)] crystallized in a orthorhombic crystal system, space group Pnab. The nickel ion was in a distorted octahedral environment, coordinated by two aryl amine N from two sulfonamides acting as monodentate ligands and four N atoms (two sulfonamidic N and two heterocyclic N) from two different sulfonamide molecules acting as bidentate ligands. Differential pulse voltammograms were recorded showing irreversible peaks at 1040 and 1070 mV, respectively, attributed to Ni(II)/Ni(III) process. [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O and [Ni(sulfapyridine)(2)] presented different antibacterial behavior against Staphylococcus aureus and Escherichia coli from the similar copper complexes and they were inactive against Mycobacterium tuberculosis.
对[Ni（磺胺异恶唑）₂（H₂O）₄]·2H₂O和[Ni（磺胺吡啶）₂]的合成、结构表征、伏安实验及抗菌活性进行了研究，并与之前报道的类似铜配合物进行了比较。[Ni（磺胺异恶唑）₂（H₂O）₄]·2H₂O结晶于单斜晶系，空间群为C2/c，其中镍离子处于略微扭曲的八面体环境中，通过杂环氮与两个磺胺异恶唑分子以及四个水分子配位。[Ni（磺胺吡啶）₂]结晶于正交晶系，空间群为Pnab。镍离子处于扭曲的八面体环境中，由两个作为单齿配体的磺胺中的两个芳胺N以及来自两个不同磺胺分子的四个N原子（两个磺胺酰胺N和两个杂环N）作为双齿配体配位。记录的差分脉冲伏安图显示分别在1040和1070 mV处有不可逆峰，归因于Ni（II）/Ni（III）过程。[Ni（磺胺异恶唑）₂（H₂O）₄]·2H₂O和[Ni（磺胺吡啶）₂]对金黄色葡萄球菌和大肠杆菌呈现出与类似铜配合物不同的抗菌行为，且它们对结核分枝杆菌无活性。
