Inorganic Chemistry Department, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Rosie Street, 020462 Bucharest, Romania.
Eur J Med Chem. 2010 Feb;45(2):774-81. doi: 10.1016/j.ejmech.2009.10.034. Epub 2009 Nov 4.
The paper presents the synthesis of complex combinations of Cu(II), V(IV) and Ni(II) with Schiff bases obtained through the condensation of 4-amino-1,5-dimethyl-2-phenyl-1H-3-pyrazol-3(2H)-one (antipyrine) with 2-hydroxybenzaldehyde, 4-hydroxy-5-methoxyisophthalaldehyde and 4,5-dihydroxyisophalaldehyde respectively. The characterization of newly formed complexes was done by (1)H NMR, (13)C NMR, UV-VIS, IR, EPR spectroscopies and molar electric conductibility studies. The effect of these complexes on proliferation of human leukemia cells (HL-60) and their antibacterial activity against Staphylococcus aureus var. Oxford 6538, Escherichia coli ATCC 10536 and Candida albicans ATCC 10231strains were studied and compared with those of free ligands.
本文介绍了通过 4-氨基-1,5-二甲基-2-苯基-1H-3-吡唑-3(2H)-酮（安替比林）与 2-羟基苯甲醛、4-羟基-5-甲氧基间苯二醛和 4,5-二羟基间苯二醛缩合反应，合成了铜（II）、钒（IV）和镍（II）的复杂配合物。新形成的配合物的表征通过（1）H NMR、（13）C NMR、UV-VIS、IR、EPR 光谱和摩尔电导率研究进行。研究了这些配合物对人白血病细胞（HL-60）增殖的影响及其对金黄色葡萄球菌变种牛津 6538、大肠杆菌 ATCC 10536 和白色念珠菌 ATCC 10231 菌株的抗菌活性，并与游离配体进行了比较。
