Shin Na Young, Lee Ae Ra, Park Hye Yoon, Yoo So Young, Kang Do-Hyung, Shin Min Sup, Kwon Jun Soo
Interdisciplinary Cognitive Science Program, Seoul National University, Seoul, South Korea.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):472-8. doi: 10.1016/j.pnpbp.2007.09.020. Epub 2007 Oct 4.
This study was a post-hoc analysis of the results from a neuropsychological battery which was conducted to investigate the frontal lobe difference between obsessive-compulsive disorder (OCD) patients with and without schizotypal personality trait (SPT), especially dorsolateral prefrontal and medial frontal functions.
Fifty-five OCD patients were divided into two groups according to their Personality Disorder Questionnaire-4+ scores. Patients with OCD with SPT (n=17) and OCD without SPT (n=38) were compared to 52 schizophrenia patients and 67 healthy subjects. Two neuropsychological tasks, the Wisconsin Card Sorting Test (WCST) and verbal fluency tests which are considered to reflect dorsolateral and medial frontal functions, were selected for an analysis.
OCD with SPT patients and patients with schizophrenia performed significantly worse than controls in both the WCST and verbal fluency tasks, whereas OCD without SPT patients showed no deficits in the same tasks. Moreover, we found no statistically significant difference in either task between patients having OCD with SPT and patients with schizophrenia.
This study indicate that OCD with SPT may have distinct patterns of neurocognitive deficit that differ from those of OCD without SPT, especially in terms of frontal lobe function.
本研究是对一项神经心理成套测验结果的事后分析，该测验旨在调查有无分裂型人格特质（SPT）的强迫症（OCD）患者之间的额叶差异，尤其是背外侧前额叶和内侧前额叶功能。
55名强迫症患者根据其人格障碍问卷-4+得分分为两组。将伴有SPT的强迫症患者（n=17）和不伴有SPT的强迫症患者（n=38）与52名精神分裂症患者和67名健康受试者进行比较。选择两项神经心理任务，即威斯康星卡片分类测验（WCST）和言语流畅性测验，以分析被认为反映背外侧和内侧前额叶功能的情况。
伴有SPT的强迫症患者和精神分裂症患者在WCST和言语流畅性任务中的表现均显著差于对照组，而不伴有SPT的强迫症患者在相同任务中未表现出缺陷。此外，我们发现伴有SPT的强迫症患者和精神分裂症患者在任何一项任务中均无统计学上的显著差异。
本研究表明，伴有SPT的强迫症可能具有与不伴有SPT的强迫症不同的神经认知缺陷模式，尤其是在额叶功能方面。
