自体血小板凝胶对颈椎前路手术中早期和晚期植骨融合的影响。
Effect of autologous platelet gel on early and late graft fusion in anterior cervical spine surgery.
作者信息
Feiz-Erfan Iman, Harrigan Mary, Sonntag Volker K H, Harrington Timothy R
机构信息
Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA.
出版信息
J Neurosurg Spine. 2007 Nov;7(5):496-502. doi: 10.3171/SPI-07/11/496.
OBJECT
In a double-blind randomized study, platelet concentrate was used to treat 50 patients who underwent anterior cervical fusion with allograft bone and internal fixation, predominantly for degenerative disc disease or soft herniated cervical disc. The goal in this study was to compare the outcomes in patients treated with and without the platelet gel.
METHODS
Patients were assessed radiographically at 6, 12, and 52 weeks and at 2 years if needed. Clinically, patients were evaluated with the visual analog scale, Neck Disability Index, Short Form-36, and a modified Prolo Scale.
RESULTS
Follow-up included 90% of the patients at 1 year and 84% at 2 years. The overall fusion rate was 84%.
CONCLUSIONS
Whereas patients with degenerative discs treated with platelet gel demonstrated early fusion at the 12-week follow-up interval, no consistent early fusion was obtained with the use of the platelet gel preparation in patients with a soft disc herniation.
目的
在一项双盲随机研究中，使用血小板浓缩物治疗50例接受同种异体骨前路颈椎融合术及内固定的患者，这些患者主要患有椎间盘退变或软性颈椎间盘突出症。本研究的目的是比较使用和不使用血小板凝胶治疗的患者的结果。
方法
在6周、12周和52周时进行影像学评估，如有需要，在2年时也进行评估。临床上，使用视觉模拟量表、颈部功能障碍指数、简明健康状况调查量表36项和改良的普罗洛量表对患者进行评估。
结果
1年时90%的患者完成随访，2年时84%的患者完成随访。总体融合率为84%。
结论
虽然接受血小板凝胶治疗的椎间盘退变患者在12周随访期时显示出早期融合，但对于软性椎间盘突出症患者，使用血小板凝胶制剂未获得一致的早期融合效果。
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