Ziaei Saeideh, Mehrnia Maryam, Faghihzadeh Soghrate
Faculty of Medical Science, Tarbiat Modarres University, Tehran, Iran.
Int J Gynaecol Obstet. 2008 Feb;100(2):130-2. doi: 10.1016/j.ijgo.2007.07.027. Epub 2007 Oct 31.
To measure levels of markers of anemia before and after delivery in women who had high hemoglobin levels during the early stage of the second trimester of pregnancy and did not receive iron supplementation during their pregnancies.
In a randomized, double-blind, placebo-controlled trial 244 women who had a hemoglobin concentration of 13.2 g/dL or greater and a serum ferritin level higher than 15 microg/L between the 13th and 18th week of pregnancy took either one 150-mg tablet of ferrous sulfate daily or placebo during their pregnancies. Markers of anemia were measured at the time of delivery and 6 weeks postpartum.
There were statistically significant differences between the 2 groups in hematocrit as well as hemoglobin and ferritin levels both at the time of delivery and 6 weeks postpartum (P<0.05), but these differences were not clinically significant.
Not using iron supplementation did not cause a considerable decrease in markers of anemia in women with a hemoglobin concentration of 13.2 g/dL or greater in the second trimester of pregnancy.
测量妊娠中期早期血红蛋白水平高且孕期未补充铁剂的女性分娩前后的贫血标志物水平。
在一项随机、双盲、安慰剂对照试验中，244名在妊娠第13至18周血红蛋白浓度为13.2 g/dL或更高且血清铁蛋白水平高于15 μg/L的女性，在孕期每天服用一片150毫克硫酸亚铁片或安慰剂。在分娩时和产后6周测量贫血标志物。
两组在分娩时和产后6周的血细胞比容以及血红蛋白和铁蛋白水平存在统计学显著差异（P<0.05），但这些差异无临床意义。
对于妊娠中期血红蛋白浓度为13.2 g/dL或更高的女性，不补充铁剂不会导致贫血标志物显著下降。
