秘鲁高海拔地区人群的死产率。
Stillbirth rates in Peruvian populations at high altitude.
作者信息
Gonzales Gustavo F, Tapia Vilma, Carrillo Carlos E
机构信息
High Altitude Research Institute, Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.
出版信息
Int J Gynaecol Obstet. 2008 Mar;100(3):221-7. doi: 10.1016/j.ijgo.2007.08.009. Epub 2007 Oct 31.
OBJECTIVE
To compare the stillbirth rates in 4 cities at different altitudes in Peru.
METHODS
The stillbirth rates from a sample of 22,662 births recorded in the Perinatal Information System database were analyzed between 2005 and 2006 for the cities of Lima (150 m), Huancayo (3280 m), Cuzco (3430 m), and Puno (3850 m).
RESULTS
Stillbirths were higher at high altitude (>3000 m) (OR 4.82; CI, 3.05-7.72) compared with low altitude. The effect of altitude was observed after controlling for socioeconomic (OR 4.29; CI, 2.61-6.93), demographic and biological (OR 4.18; CI, 2.65-6.77), maternal health care (OR 4.72; CI, 2.96-7.61), and fetal factors (OR 3.96; CI, 2.48-6.45). Inhabitants from the southern Andes demonstrated a protective effect on stillbirth rate compared with the central Andes, which may be due to an ancestry effect with longer multigenerational residence in the southern Andes population.
CONCLUSION
Stillbirth rate is higher at high altitude compared with low altitude.
目的
比较秘鲁4个不同海拔城市的死产率。
方法
分析2005年至2006年期间在围产期信息系统数据库中记录的22662例出生样本的死产率，涉及利马（海拔150米）、万卡约（海拔3280米）、库斯科（海拔3430米）和普诺（海拔3850米）这几个城市。
结果
与低海拔地区相比，高海拔地区（>3000米）的死产率更高（比值比4.82；可信区间，3.05 - 7.72）。在控制了社会经济因素（比值比4.29；可信区间，2.61 - 6.93）、人口统计学和生物学因素（比值比4.18；可信区间，2.65 - 6.77）、孕产妇保健因素（比值比4.72；可信区间，2.96 - 7.61）以及胎儿因素（比值比3.96；可信区间，2.48 - 6.45）之后，仍观察到海拔的影响。与安第斯中部地区相比，安第斯南部地区的居民对死产率具有保护作用，这可能是由于安第斯南部人口多代居住时间更长所产生的祖先效应。
结论
与低海拔地区相比，高海拔地区的死产率更高。
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