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秘鲁高海拔地区生物燃料暴露与不良出生结局之间的关联:一项配对病例对照研究。

Association between biofuel exposure and adverse birth outcomes at high altitudes in Peru: a matched case-control study.

作者信息

Yucra Sandra, Tapia Vilma, Steenland Kyle, Naeher Luke P, Gonzales Gustavo F

机构信息

Instituto de Investigaciones de la Altura, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.

出版信息

Int J Occup Environ Health. 2011 Oct-Dec;17(4):307-13. doi: 10.1179/107735211799041869.

DOI:10.1179/107735211799041869
PMID:22069928
Abstract

Nearly one-third of the Peruvian population burns biofuels for cooking. Similarly, approximately one-third of this population lives at high altitudes. Cooking with biofuels and living at high altitudes have been implicated in adverse perinatal outcomes. This study attempted to determine the risk of low birth weight (LBW) and/or preterm delivery in relation to biofuel use in inhabitants at high altitudes in Peru. A matched-case study was performed in two high-altitude cities. All subjects (n=190) were identified from public-hospital records. Cases were matched by hospital by week of birth and area of residence. Cases were defined as: women with an at-term but LBW newborn; or women with a preterm birth. Adjusted conditional logistic regression analyses were used to determine odds ratio. Fifty-two percent of the cases used biofuel whereas only 30% of the controls used biofuel. The use of biofuel for cooking was found to be strongly associated with increased risks of LBW, but was not significantly linked to preterm births.

摘要

近三分之一的秘鲁人口使用生物燃料做饭。同样,约三分之一的人口生活在高海拔地区。使用生物燃料做饭和生活在高海拔地区都与不良围产期结局有关。本研究试图确定秘鲁高海拔地区居民使用生物燃料与低出生体重(LBW)和/或早产风险之间的关系。在两个高海拔城市进行了一项匹配病例研究。所有受试者(n = 190)均从公立医院记录中识别出来。病例按出生周数和居住地区在医院层面进行匹配。病例定义为:足月但新生儿低体重的妇女;或早产的妇女。采用调整后的条件逻辑回归分析来确定比值比。52%的病例使用生物燃料,而只有30%的对照使用生物燃料。研究发现,使用生物燃料做饭与低出生体重风险增加密切相关,但与早产无显著关联。

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