对于1型糖尿病患者，随着病程延长，蹲姿会放大脉压升高幅度。
Squatting amplifies pulse pressure increase with disease duration in patients with type 1 diabetes.
作者信息
Philips Jean-Christophe, Marchand Monique, Scheen André J
机构信息
Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, Centre Hospitalier Universitaire Sart Tilman, University of Liége, Liège, Belgium.
出版信息
Diabetes Care. 2008 Feb;31(2):322-4. doi: 10.2337/dc07-1646. Epub 2007 Oct 31.
OBJECTIVE
To evaluate pulse pressure changes according to duration of type 1 diabetes and to assess the influence of posture.
RESEARCH DESIGN AND METHODS
We performed continuous measurement of blood pressure with a Finapres device during a 3 x 1 min posture test (standing, squatting, standing) in 159 type 1 diabetic patients divided into four groups according to diabetes duration (<or=10, 11-20, 21-30, and >30 years, groups 1-4, respectively) and compared the results with those of age-matched nondiabetic subjects.
RESULTS
Pulse pressure progressively increased according to type 1 diabetes duration (P < 0.0001), especially in women, but not in age-matched nondiabetic subjects (NS). Pulse-pressure increase from group 1 to group 4 was amplified in the squatting position (from 50 +/- 17 to 69 +/- 14 mmHg) compared with standing (from 44 +/- 15 to 55 +/- 12 mmHg).
CONCLUSIONS
Pulse pressure increases according to type 1 diabetes duration more in women than in men, and the squatting position sensitizes such pulse-pressure increase in both sexes.
目的
评估1型糖尿病病程与脉压变化的关系，并评估体位的影响。
研究设计与方法
我们使用Finapres设备对159例1型糖尿病患者进行了3×1分钟体位测试（站立、下蹲、站立）期间的血压连续测量。这些患者根据糖尿病病程分为四组（分别为病程≤10年、11 - 20年、21 - 30年和>30年，即1 - 4组），并将结果与年龄匹配的非糖尿病受试者进行比较。
结果
脉压随1型糖尿病病程逐渐升高（P < 0.0001），尤其是女性，但年龄匹配的非糖尿病受试者无此变化（无显著性差异）。与站立位（从44±15 mmHg升至55±12 mmHg）相比，从第1组到第4组，下蹲位时脉压升高更为明显（从50±17 mmHg升至69±14 mmHg）。
结论
1型糖尿病患者中，女性脉压随病程增加的幅度大于男性，且下蹲位会使两性的脉压升高更为明显。
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