Furmański J, Markiewicz K, Rynkiewicz A, Bieniaszewski L, Semetkowska E, Janikowska-Skłucka A, Horoszek-Maziarz S, Krupa-Wojciechowska B
II Kliniki Chorób Wewnetrznych AM, Gdaśnku.
Pol Tyg Lek. 1993;48(1-2):10-2.
In order to investigate the blood pressure-heart rate interrelation and their circadian pattern in type I diabetes mellitus, we performed ambulatory blood pressure monitoring in 28 normotensive patients without clinical nephropathy divided in two groups. Group A consisted of 14 males with short-term DM (mean 2 years, mean age 28 +/- 6 years), group B consisted of 14 males with long-term DM (mean 12 years, mean age 31 +/- 7 years). Ambulatory blood pressure monitoring revealed significantly higher night heart rate in B group (74 +/- 13 l/min vs. 62 +/- 11 l/min in A, p < 0.01) and day diastolic blood pressure (83 +/- 9 mm Hg vs. 74 +/- 8 mm Hg in A, p < 0.01) and night diastolic blood pressure (73 +/- 10 mm Hg vs. 62 +/- 8 mm Hg in A, p < 0.01). The linear regression SBP/HR equation were significantly different (p < 0.02) (HR = 0.48 x SBP + 21, r = 0.40 in A vs. HR = 0.29 x SBP + 69, r = 0.28 in B). We concluded that type I diabetes duration has significant influence on diastolic blood pressure and heart rate even in patients without diabetic nephropathy and could be related to changed sensitivity of the baroreceptors.
为了研究1型糖尿病患者的血压与心率的相互关系及其昼夜模式，我们对28例无临床肾病的血压正常患者进行了动态血压监测，这些患者被分为两组。A组由14名患有短期糖尿病的男性组成（平均病程2年，平均年龄28±6岁），B组由14名患有长期糖尿病的男性组成（平均病程12年，平均年龄31±7岁）。动态血压监测显示，B组夜间心率显著更高（74±13次/分钟，而A组为62±11次/分钟，p<0.01），日间舒张压（83±9mmHg，而A组为74±8mmHg，p<0.01）以及夜间舒张压（73±10mmHg，而A组为62±8mmHg，p<0.01）。收缩压/心率的线性回归方程有显著差异（p<0.02）（A组：心率=0.48×收缩压+21，r=0.40；B组：心率=0.29×收缩压+69，r=0.28）。我们得出结论，即使在无糖尿病肾病的患者中，1型糖尿病病程对舒张压和心率也有显著影响，这可能与压力感受器敏感性改变有关。
