Howard Caitlin T, McKakpo Uri S, Quakyi Isabella A, Bosompem Kwabena M, Addison Ebenezer A, Sun Kai, Sullivan David, Semba Richard D
Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA.
Am J Trop Med Hyg. 2007 Oct;77(4):623-6.
The pathogenesis of malarial anemia is incompletely understood. Hepcidin, a recently discovered peptide hormone, is a major regulator of iron metabolism and is thought to play a central role in the anemia of chronic inflammation. The specific aim of the study was to characterize the association between urinary hepcidin, hemoglobin, and parasitemia in 199 patients presenting for evaluation of Plasmodium falciparum malaria in Ghana. Urinary hepcidin was semi-quantitatively assessed using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. Urinary hepcidin (intensity/mmol creatinine) was associated with log parasitemia in 86 children (beta = 0.086, standard error [SE] = 0.035, P < 0.017), 31 pregnant women (beta = 0.218, SE = 0.085, P < 0.016), and 82 adults (beta = 0.184, SE =0.043, P < 0.0001). Urinary hepcidin was not significantly associated with hemoglobin or anemia. Urinary hepcidin is more strongly associated with parasitemia than hemoglobin or anemia among patients with acute P. falciparum malaria in Ghana.
疟疾性贫血的发病机制尚未完全明确。铁调素是一种最近发现的肽类激素，是铁代谢的主要调节因子，被认为在慢性炎症性贫血中起核心作用。该研究的具体目的是在加纳199例因恶性疟原虫疟疾前来评估的患者中，描述尿铁调素、血红蛋白和疟原虫血症之间的关联。使用表面增强激光解吸/电离飞行时间质谱法对尿铁调素进行半定量评估。尿铁调素（强度/毫摩尔肌酐）在86名儿童（β = 0.086，标准误[SE] = 0.035，P < 0.017）、31名孕妇（β = 0.218，SE = 0.085，P < 0.016）和82名成年人（β = 0.184，SE = 0.043，P < 0.0001）中与疟原虫血症对数相关。尿铁调素与血红蛋白或贫血无显著关联。在加纳急性恶性疟原虫疟疾患者中，尿铁调素与疟原虫血症的关联比与血红蛋白或贫血的关联更强。
