Kim Dong-Min, Lim Sung-Chul, Won Kyung Jun, Choi Yeon-Joo, Park Kyung-Hee, Jang Won-Jong
Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Korea.
Am J Trop Med Hyg. 2007 Oct;77(4):719-22.
We describe a case of interstitial pneumonia that was confirmed as scrub typhus by immunohistochemical (IHC) staining of an eschar. When a patient presents with interstitial pneumonia accompanied by generalized lymphadenopathy on the thoracic CT scan, clinicians should suspect scrub typhus, especially when the patient has a history of travel to a scrub typhus-endemic area. IHC staining on an eschar revealed invasion by Orientia tsutsugamushi coccobacilli of the patient's sweat ducts and glands as well as vascular endothelium. IHC staining of an eschar could be used as an early-confirmation diagnostic method to establish scrub typhus.
我们描述了一例间质性肺炎病例，通过对焦痂进行免疫组织化学（IHC）染色确诊为恙虫病。当患者出现间质性肺炎且胸部CT扫描显示全身淋巴结肿大时，临床医生应怀疑恙虫病，尤其是当患者有前往恙虫病流行地区的旅行史时。对焦痂进行的IHC染色显示，恙虫东方体短杆菌侵入了患者的汗腺和腺体以及血管内皮。焦痂的IHC染色可作为确诊恙虫病的早期诊断方法。
