来自扁秆谷精草的黄酮类化合物和一种萘并吡喃酮及其诱变活性。

Flavonoids and a naphthopyranone from Eriocaulon ligulatum and their mutagenic activity.

作者信息

da Silva Marcelo Aparecido, Oliveira Ana Paula Siqueira, Sannomiya Miriam, Sano Paulo Takeo, Varanda Eliana Aparecida, Vilegas Wagner, dos Santos Lourdes Campaners

机构信息

Department of Organic Chemistry, Instituto de Química de Araraquara, São Paulo State University (UNESP), São Paulo, Brazil.

出版信息

Chem Pharm Bull (Tokyo). 2007 Nov;55(11):1635-9. doi: 10.1248/cpb.55.1635.

DOI:10.1248/cpb.55.1635

PMID:17978526

Abstract

A new acylated flavonoid, 6,4'-dimethoxyquercetin-3-O-beta-D-6''[3,4,5-trihydroxy (E)-cinnamoyl]glucopyranoside, and a naphthopyranone dimer, named eriocauline, together with 2 other known flavonoids, 6-methoxyapigenin-7-O-beta-D-glucopyranoside and 6-methoxyapigenin-7-O-beta-D-allopyranoside, have been isolated from the capitulae of Eriocaulon ligulatum. The compounds were identified using spectroscopic methods (HR-ESI-MS, and 1-D and 2-D NMR). The methanol extract exhibited mutagenic activity in the Salmonella/microsome assay, in strains TA100, TA97a and TA102 and for dichloromethane extract tested in strain TA98.

摘要

从扁秆谷精草的头状花序中分离出一种新的酰化黄酮类化合物6,4'-二甲氧基槲皮素-3-O-β-D-6''[3,4,5-三羟基（E）-肉桂酰]吡喃葡萄糖苷和一种名为谷精草素的萘并吡喃酮二聚体，以及另外两种已知的黄酮类化合物6-甲氧基芹菜素-7-O-β-D-吡喃葡萄糖苷和6-甲氧基芹菜素-7-O-β-D-阿洛吡喃糖苷。这些化合物通过光谱方法（高分辨电喷雾电离质谱以及一维和二维核磁共振）进行鉴定。甲醇提取物在鼠伤寒沙门氏菌/微粒体试验中，对TA100、TA97a和TA102菌株表现出诱变活性，二氯甲烷提取物在TA98菌株中进行测试时也有诱变活性。