用高效液相色谱-电喷雾串联质谱法（HPLC-ESI-IT-MSn）分析并评价智利土瓶草甲醇提取物中的类黄酮和萘并吡喃酮及其致突变活性。
Characterization of flavonoids and naphthopyranones in methanol extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MSn and their mutagenic activity.
机构信息
Department of Organic Chemistry, Institute of Chemistry, UNESP-Sao Paulo State University, Araraquara CEP 14800-900, Sao Paulo, Brazil.
出版信息
Molecules. 2012 Dec 27;18(1):244-62. doi: 10.3390/molecules18010244.
Abstract
A HPLC-ESI-IT-MSn method, based on high-performance liquid chromatography coupled to electrospray negative ionization multistage ion trap mass spectrometry, was developed for rapid identification of 24 flavonoid and naphthopyranone compounds. The methanol extracts of the capitulae and scapes of P. chiquitensis exhibited mutagenic activity in the Salmonella/microsome assay, against strain TA97a.
摘要
建立了一种基于高效液相色谱-电喷雾负离子多级串联质谱联用技术的 HPLC-ESI-IT-MSn 方法，用于快速鉴定 24 种类黄酮和萘并吡喃酮类化合物。小冠毛菊头状花序和花葶甲醇提取物对鼠伤寒沙门氏菌/微粒体试验中的 TA97a 菌株具有致突变活性。
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