针对抑制金黄色葡萄球菌及其他革兰氏阳性病原体中细胞表面蛋白锚定的新型抗感染药物的最新进展。
Recent advances towards new anti-infective agents that inhibit cell surface protein anchoring in Staphylococcus aureus and other gram-positive pathogens.
作者信息
Suree N, Jung M E, Clubb R T
机构信息
Department of Chemistry & Biochemistry, Molecular Biology Institute, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095-1570, USA.
出版信息
Mini Rev Med Chem. 2007 Oct;7(10):991-1000. doi: 10.2174/138955707782110097.
PMID:17979801
Abstract
Sortase enzymes are attractive targets for the development of new anti-infective agents against Gram-positive pathogens because they covalently anchor virulence factors to the cell wall. Here we review what is known about the mechanism of sortase mediated protein anchoring and discuss recently identified inhibitors of this new important enzyme family.
摘要
分选酶是开发针对革兰氏阳性病原体的新型抗感染药物的有吸引力的靶点，因为它们将毒力因子共价锚定到细胞壁上。在这里，我们综述了关于分选酶介导的蛋白质锚定机制的已知信息，并讨论了最近发现的这个重要新酶家族的抑制剂。
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