Logvinenko N S, Svitasheva N G, Solenov E I, Ivanova L N
Fiziol Zh SSSR Im I M Sechenova. 1989 Feb;75(2):251-6.
Specific binding of aldosterone by crude membrane fraction, the affinity and maximal concentration of cytosolic receptors of aldosterone were studied in the kidney cortex of the Wistar rats as well as the plasma level and adrenal biosynthesis of aldosterone. The specific binding of aldosterone was found to increase in membrane fraction and to decrease in cytosol during kidney maturation. The affinity of the cytosol receptors to aldosterone did not change in the same period. The level of biosynthesis in adrenals and plasma concentration of aldosterone was higher in adult rather than in young rats. The membrane binding of aldosterone seems to take part in the mechanism of cell sensitivity to aldosterone.
研究了醛固酮在Wistar大鼠肾皮质中的粗膜部分的特异性结合、醛固酮胞质受体的亲和力和最大浓度，以及醛固酮的血浆水平和肾上腺生物合成。发现醛固酮的特异性结合在肾脏成熟过程中在膜部分增加而在胞质溶胶中减少。同期醛固酮胞质受体的亲和力没有变化。成年大鼠肾上腺中的生物合成水平和醛固酮的血浆浓度高于幼年大鼠。醛固酮的膜结合似乎参与了细胞对醛固酮的敏感性机制。
