Sólyom J, Siklós P, Németh M
Endokrinologie. 1975 Feb;64(3):333-8.
60 min after rapid bleeding (1.5--2.0 per cent of b. w.) both aldosterone and corticosterone production rate by quartered rat adrenals were found to be elevated. However, no difference was observed in the rate of aldosterone and corticosterone production by capsular adrenals of sham operated and hypovolaemic rats. Corticosterone production rate by decapsulated adrenals was much more higher after haemorrhage than in the control group. The same alterations could be observed incubating adrenal tissue with ACTH (0.3 mug per ml). Steroid production rate by quartered adrenals of sodium deficient rats was not affected by high in vitro concentration of angiotensin II (2.5 mug per ml). It is concluded that the effect of acute blood loss on corticosteroid biosynthesis of the rat is mediated by ACTH alone.
快速失血（体重的1.5 - 2.0%）60分钟后，发现四分体大鼠肾上腺的醛固酮和皮质酮生成率均升高。然而，假手术组和低血容量大鼠的包膜肾上腺醛固酮和皮质酮生成率未观察到差异。出血后，去包膜肾上腺的皮质酮生成率比对照组高得多。用促肾上腺皮质激素（每毫升0.3微克）孵育肾上腺组织也可观察到相同的变化。高体外浓度的血管紧张素II（每毫升2.5微克）对缺钠大鼠四分体肾上腺的类固醇生成率没有影响。得出的结论是，急性失血对大鼠皮质类固醇生物合成的影响仅由促肾上腺皮质激素介导。
